Wednesday’s Market Movers: Weight-Loss Deals, Mall Comebacks, and Copper’s Slide

Wednesday, November 05, 2025


​The Diet Drug Deal Shaking Up Big Pharma
The next trading session could see plenty of movement in the healthcare sector as reports surface that the White House is working on a deal with Eli Lilly and Novo Nordisk to bring their blockbuster weight-loss drugs under the Medicare and Medicaid umbrella.

Eli Lilly’s stock has been on a tear — up 5.1% in just two days and 10.6% in a week — as investors cheer the potential for massive new government-backed demand. Novo Nordisk, however, hasn’t shared the same luck; its shares are down 2.5% in two days and nearly 19% this month as pricing and competition weigh on sentiment.

The news has turned both companies into must-watch tickers for Wednesday’s session, especially with Novo Nordisk’s CEO set to appear on CNBC’s Squawk Box to discuss the potential policy shift.

Retail Rebounds: The Mall Stocks Are Alive
Contrary to the “malls are dead” narrative, retail real estate is quietly flexing again. CNBC’s Jim Cramer highlighted Simon Property Group’s strong quarter on Mad Money, noting steady foot traffic and healthy retail tenants.

Simon Property shares rose 3.4% on Tuesday, leaving them just 4% below their March high. Fellow mall operators Tanger and Macerich followed suit, gaining 2.7% and 2.1%, respectively.

Cramer’s verdict: “The mall’s not dying — it’s just evolving.”

Tech Trouble: Paycom and Paychex Plunge
It wasn’t a great day for HR software players. Paycom Software hit its lowest point since October 2024, down 32% since June, while Paychex slid to levels unseen since November 2023, dropping 29% over the same period.

The two firms — both in payroll and human resources software — have faced investor fatigue amid tightening corporate spending and rising competition in the automation space.

Commodities Cool Off: Copper, Gold, and Silver Slide
Commodities continued to lose shine on Tuesday. Copper hit a three-week low, now down 8%, matching gold’s 8% decline over the same stretch. Silver has fallen even further, down 12% since mid-October.

The VanEck Gold Miners ETF (GDX) is down 11.4% in a month and about 20% below its October 16 peak — a sign investors are pulling back from precious metals as the dollar strengthens.

Crypto Breaks Below Six Figures
Bitcoin briefly broke below the $100,000 mark before recovering to just over $101,000, marking a 17% monthly drop. Trading platform Coinbase is down 32% since July, while crypto miner Cleanspark has lost 31% since mid-October.

The broader crypto ecosystem continues to cool off as investors rotate into more stable sectors amid growing uncertainty around regulation and tariffs.

Harley-Davidson’s Tariff Trouble
Harley-Davidson reported better-than-expected earnings but saw its stock tumble 6.5% after revealing a 5% decline in motorcycle sales and growing tariff costs. The company said tariffs added $27 million in expenses this quarter — more than double last quarter’s $13 million — and forecast a full-year hit between $55 million and $75 million.

Despite producing all its core products in the U.S., Harley says global tariffs remain “ongoing and uncertain.” The stock has now fallen 16% year-to-date after two months of losses.

EV Watch: Lucid and Rivian in the Spotlight
Electric vehicle makers Lucid Group and Rivian are up next with earnings reports due after the bell Wednesday. Analysts expect tariff-related headwinds to be a key storyline, with Lucid previously noting a $54 million tariff impact last quarter.

Lucid shares remain 55% off their 52-week high, while Rivian is down 27% from its own peak. Meanwhile, the Global X Lithium & Battery Tech ETF (LIT) sits 5% below its October 30 record, suggesting investors are bracing for more turbulence in the EV and battery sectors.

The Takeaway: A Market in Motion
Wednesday’s session is shaping up to be a tug-of-war between policy-driven optimism and profit-taking fatigue. Weight-loss drugs may lift pharma, mall operators could surprise again, and copper’s drop might ripple through industrials.

​But with Bitcoin dipping and tariffs haunting both Harley and EV makers, it’s clear the market’s next move won’t be in one direction — it’ll be a fight between winners riding new trends and losers struggling to shake old ones.